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Pan Am Flight 103 was a regularly scheduled Pan Am transatlantic flight from Frankfurt to Detroit via London and New York. On 21 December 1988, N739PA, the aircraft operating the transatlantic leg of the route was destroyed by a bomb, killing all 243 passengers and 16 crew in what became known as the Lockerbie bombing. Large sections of the aircraft crashed onto a residential street in Lockerbie, Scotland, killing 11 people on the ground. With a total of 270 people killed, it is the deadliest terror attack in the history of the United Kingdom. Following a three-year joint investigation by Dumfries and Galloway Constabulary and the US Federal Bureau of Investigation, arrest warrants were issued for two Libyan nationals in November 1991. In 1999, Libyan leader Muammar Gaddafi handed over the two men for trial at Camp Zeist, Netherlands, after protracted negotiations and UN sanctions.